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Rev-erb has shown neuroprotective properties in Parkinsons disease, as the loss of its rhythmicity in the substantia nigra of affected patients is associated with exacerbated microglial activation and increased inflammatory markers, conditions that are attenuated following pharmacological reactivation of Rev-erb (Kou et al., 2022)

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When he befriends grieving widow Iris, who also works in the same building, she helps him to read, and a blossoming romance develops