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However, the effects of statins are not limited to decreasing lipid levels

One of the most striking observations from these studies is that only a small fraction of the signalling changes seen in insulin resistance involved canonical insulin signalling proteins [3234]

In mice, it lessens the capacity of mouse bone marrow derived macrophages from producing Il-12p40, IL-10, and IFN- -induced production, while also slowing antigen processing by phagocytic cells (97100)

Prolonged exposure to cortisol can impair the function of the hippocampus, a brain region crucial for memory formation and emotional regulation

Optional 4 week break after week 12, then resume at maintenance dosing