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This often includes patients with: Pernicious anemia, a condition where the body cannot absorb B12 due to a lack of intrinsic factor, a protein produced in the stomach

In some cases, though, the cause may be thyroid, hepatitis, infection, or cancer

By contrast, in an updated meta-analysis of 86 published studies of the association of the polymorphism with CHD, the excess CHD risk in TT homozygotes compared to CC homozygotes was 15%

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