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Neurosci Biobehav Rev 103:305315 Suzuki K, Miyamoto M, Miyamoto T, Uchiyama T, Watanabe Y, Suzuki S, Kadowaki T, Fujita H, Matsubara T, Sakuramoto H, Hirata K (2017) Istradefylline improves daytime sleepiness in patients with Parkinsons disease: an open-label, 3-month study

These patients can collect their own blood samples at home and send their samples to the hospital

Instead of asking 'why not stack them,' the question becomes 'what specific outcome justifies adding a second compound with incomplete human safety data?' For research exploring maximal metabolic intervention where single-agent tirzepatide has plateaued, the stack may be defensible

Renaud, et al

What is Non-Alcoholic Fatty Liver Disease (NAFLD)