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Aggrecan degradation in human intervertebral disc and articular cartilage

Neuroinflammation peaked during demyelination (TNF-, IL-1, IL-6, IL-17) and only partially resolved, suggesting that a balanced inflammatory response may aid remyelination

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That distinction matters because a more aggressive schedule can blur cause and effect

Due to various problems during sectioning and staining, 7 samples were excluded after the staining procedure, distributed in the following groups: 2 for collagen 1 (RL 1 week, FL 20 weeks), 3 for collagen 3 (ML 1 week, RL 1 week, RL 2 weeks), and 2 for elastin (RL 1 week, FL 3 weeks)