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Large-scale, randomized controlled trials are critically needed to establish definitive efficacy for specific clinical indications and to compare these peptides with established therapies

Oxidative stress can lead to lipid peroxidation, a process in which ROS react with lipids in cell membranes, resulting in the formation of lipid peroxides and aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) [9]

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Milk thistle has documented mild interactions with CYP3A4 and P-glycoprotein substrates, potentially affecting absorption or metabolism of certain medications

Some women report intermittent hot flashes up to 10 years after menopause