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We found that aggressive TNBC cells are characterized by higher expression of FADS1/2, leading to enhanced PUFA availability and thus becoming more sensitive to ferroptosis-promoting insults, a finding validated both in vitro and in vivo

Vader P, Mol EA, Pasterkamp G, Schiffelers RM (2016) Extracellular vesicles for drug delivery

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While no antagonistic interactions were observed, this screening approach identified synergistic effects between loss of ABCC1 or ABCA2 and Venetoclax treatment (Fig