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Since 2012, regulatory agencies such as the FDA and EMA have officially recognized the pivotal role of MS approaches in predicting the risk of DDIs during new drug development and have issued corresponding regulatory guidance [136, 137]

Further research is needed on the stability of microgels under acidic and oxidative stress conditions

Furthermore, the stringent regulatory requirements for new multi-target therapies make the approval process more suitable for single-target drugs, necessitating adjustments that could hinder progress and increase costs

However, one of the products, called NAPQI, is toxic to the body

297 , R12831292 (2009)