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Furthermore, existing experimental research primarily targets single pathways or signals, neglecting the interactions between different targets or pathways

Four trials were rated to have a low risk of bias (Reference Alperet, Rebello and Khoo24,Reference Hochkogler, Schweiger and Rust29,Reference Ohnaka, Ikeda and Maki38,Reference Wedick, Brennan and Sun44) , five trials were rated to have some concerns (Reference Bak and Grobbee25,Reference Bhn, Croft and Burrows27,Reference Kobayashi, Kawano and Ukawa31,Reference Lecoultre, Carrel and Egli32,Reference Mortazavi, Paknahad and Hasanzadeh34) and the other twelve trials were rated to have a high risk of bias (Reference Ahmed Al-Naggar, Osman and Abdulghani23,Reference Basu, Betts and Mulugeta26,Reference Cardoso, Salgado and Cesar28,Reference Kajimoto, Kajimoto and Yabune30,Reference Martnez-Lpez, Sarri and Mateos33,Reference Mousavi, Vafa and Neyestani35Reference Nabi, Sedighinejad and Haghighi37,Reference Revuelta-Iniesta and Al-Dujaili39,Reference Superko, Bortz and Williams40,Reference van Dusseldorp, Katan and van Vliet42,Reference Vieira Senger, Schwanke and Gomes43) (online Supplementary Table 3)

Maciejczyk, M., Taranta-Janusz, K., Wasilewska, A., Kossakowska, A

An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration

US 8598118, Harding JW, Wright JW, Benoist CC, Kawas LH, Wayman GA, "Hepatocyte growth factor mimics as therapeutic agents", issued 3 December 2013 "Facilitation of hippocampal synaptogenesis and spatial memory by C-terminal truncated Nle1-angiotensin IV analogs"