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The knowledge about functional expression of transporters at the BBB and structural requirements for substrate binding and translocation via the transporters gives tempting opportunity for rational design and development of drugs, prodrugs and nanocarriers, which can utilize the specific BBB transporter for brain delivery of CNS drugs (71, 72)

Most individuals find 0.1 to 0.15 mg daily sufficient for chronic condition management

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"Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu(2+)"