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Over the last 30 years the number of diagnosed cases has increased from 0.4-0.5 to 4.0 per 1000 for autistic disorder and from 2 to 7.7-9.9 per 1000 for autism spectrum disorders [13] which is largely attributable to broadening diagnostic criteria, younger age at diagnosis and improved case ascertainment [4]

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We thank the Wellcome Trust and the Medical Research Council for funding, the European Union framework 5 and the Netherlands Organization for Scientific Research for support