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For instance, the downregulation of GPx4 has been correlated with the manifestation of radiation injury in various tissues including the intestine, hemopoietic system, lung, cardiovascular system, ovary, and skin of the murine model though enhancing the ferroptosis mode of cell death [67]

The approach of empirical supplementation coupled solely with serum calcium monitoring is not recommended, as hypercalcemia represents a late manifestation of Vitamin D 3 intoxication and does not reflect Vitamin D 3 status or tissue-level activity (68, 155)

Zhao XY, Zhang P, Huang LS, Zhang XH

Biomaterials 188 , 6373 (2018)

Clinical risk management of Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum