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Second, we excluded participants with gestational diabetes from the study samples and fit the linear regression and DiffVar models in the rest of the samples

10.1200/JCO.23.00903 12 BasilicoC.PennacchiettiS.VignaE.ChiriacoC.ArenaS.BardelliA.et al (2013)

Similarly, oral acute toxicity tests at 3,000 mg/kg and 5,000 mg/kg resulted in no deaths, suggesting an LD 50 greater than 5,000 mg/kg, classifying it as practically non-toxic and safe (709)