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It is imperative to exclude other causes of fatigue such as iron deficiency and thyroid dysfunction before addressing the drivers of HPA axis dysfunction

Disinfect the stoppers of both vials with an alcohol wipe or any antiseptic solution before use to prevent bacterial contamination and eliminate the risk for infections

McDonald I, Connolly M, Tobin AM

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Inflammation of IVD may be characterized by elevated expression of proinflammatory molecules such as interleukins (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, and IL-17), TNF-, IFN-, chemokines and prostaglandin E2 (PGE2), leading to the development of IDD and LBP (Molinos et al., 2015