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In light of the prevalence of these CBS gene variants, especially C699T, which has the most science examining up regulation, it seems unlikely to me that most people should not be taking extreme measures with their diets as the result of heterozygous CBS SNPs

Arch Toxicol 86(4):521534 Roohani N, Hurrell R, Kelishadi R, Schulin R (2020) Zinc and its importance for human health: an integrative review

Role of glutathione in intracellular amyloid-alpha precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity

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Overexpression of MTHFD1 in hepatocellular carcinoma predicts poorer survival and recurrence