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There are also increasing reports that abnormal glucocorticoid signaling and altered glial-neuron communication in CNS are essential for emotional response (Horchar and Wohleb, 2019

& Adibkia, K

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Hence, NRF2 has emerged as an attractive target for the clinical intervention of neurodegeneration and in the following section, we describe the role of NRF2 in AD, PD, MS and ALS