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2000 Nov;72(5):1135-41

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30 In a methionine- and choline-deficient (MCD) diet-induced NASH mouse model, curcumin (100 mg/kg for 8 weeks) effectively suppressed M1 macrophage activation, leading to reduced expression of pro-inflammatory cytokines IL-1beta and TNF-alpha, thereby attenuating hepatic inflammation and liver injury in NASH

Moreover, HMGB1, a key mediator of TMAO-induced endothelial dysfunction, might serve as a significant target for treating endothelial dysfunction and its related cardiovascular diseases