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In such environments, M.tb switches to fatty acid metabolism to enter a persistent state

10.1016/j.dnarep.2009.08.003 167 JohnsonW

Disrupted Ca 2+ homeostasis can lead to compromised perfusion and result in ER stress

Enzyme-linked immunosorbent assay (ELISA) After drug treatment, the intracellular CXCL8 levels were measured using the appropriate ELISA kit (ABclonal, China) according to the manufacturers protocol

With the possibility of each cell line receiving different amounts of the drug being discarded, we focused in understanding if the DNA repair capacity, as showed by the XPF knockdown in the most resistant lineage, could explain the different sensitivity to cisplatin among them