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[371] Given the limited applicability of the trials' exclusion criteria to many RP patients, it's unlikely that future trials will include such individuals

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Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria)

60,67,71,72,73 Further research found that AN extract induces the transformation of fibroblasts into MFBs through multiple molecular mechanisms, including activation of PLC/IP3/Ca2 + and Rho kinase regulating cell contraction, as well as direct phosphorylation by NF-B, JNK, P38 MAPK mediating CTGF production

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