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Over about 84 weeks, people taking CagriSema lost around 23% of their body weight, while those on Zepbound lost about 25.5% at its highest dose

This activates the intrinsic pathway via mitochondrial outer membrane permeabilization, releasing cytochrome C and forming the apoptosome complex with apoptotic protease activating factor-1 (Apaf-1) and procaspase-9 (Hashemi et al