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While ETC activity drives pro-ferroptotic ROS generation via electron leakage, it is also essential for anti-ferroptotic enzymes (e.g., DHODH and GPD2) that reduce mitochondrial coenzyme Q (CoQ) to ubiquinol (CoQH 2 ) (113115)

Oxidation of methionine can generate two diastereomeres that are reduced by two different non-related enzyme families, namely MSRA (reducing methionine- S -sulfoxide) and MSRB (reducing methionine- R -sulfoxide) [52]

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In the current study, APAP reduced the diversity of intestinal flora in mice, which was reduced through GC treatment, and hence, the liver restored its physiology upon application of GC

In antioxidant defence, glutathione is very important because it helps cells deal with oxidative stress and keep their internal environment stable