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Ang III- and Ang II-induced dose-dependent increases in renal perfusion pressure were both enhanced in SHR compared with WKY rats, 103 but kidneys of SHR displayed higher activity of aminopeptidase A, the principal enzyme that hydrolyzes Ang II to Ang III, 104 suggesting that Ang III could contribute to the enhanced renal response to Ang II in the SHR

Systemic supplementation typically begins with low doses and the minimum effective amount

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doi: 10.1007/s13300-022-01258-4 137 MullerTDFinanBBloomSRDAlessioDDruckerDJFlattPRet al