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Peptides like PT-141 act directly on the central nervous system to activate the pathways responsible for sexual desire

For further reading, see published research on BPC-157 on PubMed

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however, this therapeutic effect is abolished following vagotomy, indicating that the gut microbiotas influence on behavior is mediated via vagal signaling (Sgritta et al., 2019)

Similarly, although some data suggest that THRB gene variants may affect thyroid hormone action and contribute to immune dysregulation, these findings have not been consistently replicated, highlighting the need for further well-powered studies in diverse cohorts (Table 2)