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Nonetheless, deploying polymerdrug conjugates, particularly in multi-drug regimens, presents hurdles, including identifying the ideal drug-to-therapeutic agent ratios and addressing concerns related to low drug loading capacities [56, 57, 60]

Carnitine Orotate Complex Ameliorates Insulin Resistance and Hepatic Steatosis Through Carnitine Acetyltransferase Pathway

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It has been proposed that a feedback process that compensates for mitochondrial flaws includes mutant mtDNA and a malfunctioning respiratory system, which raises ROS production in the mitochondria and induces more oxidative damage 89,90