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Activation of these TLRs triggers the NF-B and mitogen-activated protein kinase (MAPK) pathways, leading to the production of proinflammatory cytokines (TNF-, IL-6, IL-1) and chemokines (CXCL-1, CXCL-2) (Wang et al., 2019)

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SDF Only three studies, with a total of 68 AOX-treated patients and 67 placebo-treated or untreated controls, were included in the analysis of SDF [29, 52, 56]

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