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While early investigations focused on the impact of high concentrations of Mn on the mitochondria and subsequent oxidative stress, current studies have attempted to elucidate the cellular and molecular pathways involved in Mn toxicity

78 Although the role of D-lactylation in vivo may substantially differ from that of L-lactylation, experimental evidence with p300 inhibitors (A-485), HDAC inhibitors (TSA), and JQ-1 indicates that both enzymatic and nonenzymatic lactylation marks are recognized indiscriminately by reader proteins

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Ubiquitin specific protease-13 independently regulates parkin ubiquitination and alpha-synuclein clearance in alpha-synucleinopathies

doi: 10.1016/S2213-8587(13)70218-3 93