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However, due to the spatial patterning of the two layers, local protein delivery to the tissue was dependent on scaffold orientation during implantation (Mooney et al., Alternately, by forming PLG scaffolds with microspheres already containing PDGF, which are subsequently mixed with VEGF, sustained release of both factors was achieved, with VEGF being released more rapidly than PDGF

Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology

True allergic reactions are uncommon but possible

REFERENCES Benet LZ, Hoener B: Changes in plasma protein binding have little clinical relevance