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Antibody positivity was observed beginning on dosing day 14, and 1/24, 6/24, and 9/24 animals were determined as true positives on dosing day 14, dosing day 28, and recovery day 29, respectively (Fig

In addition, dsRBPs act as catalysts not only for the resolution of the ends of the dsRNAs but also for their crossing of the plasmamembrane, a crucial barrier for uptake (section 7.2.2)