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Deficiency in B12 is linked to symptoms such as low mood, irritability, poor memory, and anxiety

Discordance Between Endocrine and Paracrine/Autocrine IGF-I An important example of metabolic and mitogenic consequences of an unbalanced endocrine versus autocrine/paracrine insulin-GH-IGF-axis comes from observations in children and adolescents with type 1 diabetes (Figure 5)

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But contrary to strong opinions from social media groups who say that injections are the only way to go for your lifetime, there are plenty of reports of patients doing well with B12 supplementation in higher doses, such as 2000mg or higher

This can lead to fatigue, lethargy, and even resistance to weight loss, resulting from a slowed metabolism