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This pathological process is further amplified through a vicious cycle wherein excess ammonia induces inducible NOS (iNOS)-mediated GS nitration (Cudre-Cung et al

Sener G, Paskaloglu K, Satiroglu H, Alican I, Kamaz A, Sakarcan AJJocp

Similarly, upregulation of the anti-apoptotic protein Bcl-2 protects cancer cells from castration-induced apoptosis 155

We also discuss how the outcomes associated with different timing of therapeutic intervention are contributing to our understanding of the biology and pathogenesis of SMA