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Multi-Dose Capability: Unlike "Sterile Water for Injection" (which is single-use), the preservative in bacteriostatic water allows the vial to be re-entered multiple times

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2.4 Premedication and Concomitant Medications to Mitigate Toxicity Vitamin Supplementation Initiate folic acid 400 mcg to 1000 mcg orally once daily, beginning 7 days before the first dose of pemetrexed for injection and continuing until 21 days after the last dose of pemetrexed for injection [see Warnings and Precautions (5.1)]