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Notably, multiple APP and Tau models exhibit NPS-related deficits, suggesting that these behavioral changes may not be tied to specific pathologies but rather to some shared factors such as alterations in neuronal activity or synaptic functions

M.CummingsJ

Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS

Initially, the enzyme -glutamyl cysteine synthetase (-GCS) facilitates the combination of cysteine with glutamate, leading to the creation of -glutamylcysteine

That means it activates three different receptors simultaneously: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon