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Randomized controlled trial of once-per-week intermittent fasting for health improvement: the WONDERFUL trial

Cellular redox balance relies on enzymatic [e.g., superoxide dismutase and glutathione peroxidase (GPX)] and non-enzymatic [e.g., glutathione (GSH)] antioxidants to neutralize ROS (3)

This suggests that variations in the techniques used, biological samples analyzed, timing of sampling, and subject selection may be the cause of discrepancies (Geyik et al., 2016

Acknowledgements This study was partially supported by grants of the Russian Foundation for Basic Research (11-04-00843, 12-04-31528, 13-04-40083-), and the Molecular and Cell Biology Program of the Russian Academy of Sciences, and the Federal Program for Support of Scientific Schools of the Russian Ministry of Science and Education

In contrast, in mutant animals where local IGF-1 action is impaired, most animals died shortly after birth and those that did survive had severe growth defects [3,142,143] supporting the importance of locally produced IGF-1