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Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

Once reconstituted with bacteriostatic water, keep refrigerated and handle under sterile laboratory conditions

In a preferred embodiment, the process of the invention uses special equipment for crystallisation, as it has been observed that particular stirrers with low shear strength give rise to rapid, complete dissolution of the product in amorphous form and better reproducibility of precipitation, especially when the alpha crystalline form is to be obtained

If the agent is a non-hormonal or hormonal antineoplastic, use 96401 or 96402 instead

Here we present a versatile and transferable, genetically stable system based on a low-temperature-controlled N-terminal degradation signal (lt-degron) that allows reversible and switch-like tuning of protein levels under physiological conditions in vivo