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Studies have confirmed that iron deposition in the substantia nigra is an important factor in the degeneration of DA neurons

LMP2B is the smaller isoform that structurally lacks a short cytoplasmic N-terminal domain that harbors an essential survival signal known as immunoreceptor tyrosine-based activation motif (ITAM) (127)

Basal lipid peroxidation in substantia nigra is increased in Parkinsons disease

To study the immunometabolic characteristics associated with response to CAR T cell therapy, we investigated the pre-infusion CAR T cell products and biological samples from a cohort of sixteen patients treated in our clinical trial, all of whom responded to CD19-CAR T cell therapy

Yokoyama, S., Perera, P.-Y., Waldmann, T