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Some studies have suggested that GH and IGF-1 can increase muscle mass and reduce body fat, but its mostly been shown in animals and people with low levels of GH, like the elderly or those with a medical issue causing a deficiency

age of onset, duration, medication and disease activity index) were obtained through medical record review and personal history

But only if your gut actually absorbs it

The 2018 paper in Biochemical Pharmacology gave obese mice a membrane-permeable NNMT inhibitor and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with the mice eating the same amount as before, and the authors noting the inhibitors did not impact total food intake nor produce any observable adverse effects [1]