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FIGURE 2 4.1 Ferroptosis promotes pancreatic tumour and hepatocellular carcinoma development and progression by regulating metabolic pathways ACSL4, an enzyme involved in synthesizing phospholipids from PUFAs plays a crucial role in ferroptosis (Yuan et al., 2016)

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While combining PRMT5 inhibition with PD-L1 therapy has potential benefits, it has been reported that the MTA-rich environment in MTAP -negative cancer cells stimulate the immunosuppressive (M2) state in macrophages through activation of the adenosine A 2B receptor (115), thus inhibiting immune invasion

Increasing extracellular glutamate levels limits the uptake of cystine, gradually inducing ferroptosis

Thus, while it is clear that agonism of Hcar2 by niacin or other compounds leads to an increase in intracellular Ca 2+ and a reduction in inflammation, the specific pathways remain to be fully elucidated