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The spirosuccinimide of ( S )-dHTC1 engages the IMiD-binding site of CRBN but, interestingly, it adopts a slightly different pose in the ternary complex compared to what was revealed by the cocrystal structure of the binary complex (Extended Data Fig

Elderly patients, who are more prone to malnutrition, may need preoperative nutritional support or even surgery delays if severe deficiencies are identified [16]