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Dealing with danger in the CNS: the response of the immune system to injury

All cited studies are conducted in cellular or rodent systems

After endocytotic uptake and retrograde transport through the Golgi and ER to the cytosol, the K28 -subunit is ubiquitinated and proteasomally degraded, and the -subunit exerts its lethal effect in the nucleus, blocking DNA synthesis, causing cell-cycle arrest in early S phase

Therefore, elucidating the mechanisms of action of these peptides is of great interest to researchers working in molecular biology, pharmacology, and medicine

Cellular senescence, activation of the reninangiotensinaldosterone-system and vascular dysfunction might contribute to RN, but only limited data is available