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Bhrigu, B., Sharma, S., Kumar, N

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Emerging therapies, including TYK2 and RORt inhibitors, offer new hope with potentially improved safety margins, yet their long-term hepatic effects remain to be fully elucidated

Oxid Med Cell Longev 2021:6643382

However, these mice do not display the TDP-43 pathology that is present in almost all cases of ALS, and therefore they have been increasingly criticized as a disease model