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An alternative pathway for GSH transport has been proposed, analogical to the animal gamma-glutamyl cycle, in which GSH is moved across the membrane through combination of degradation, amino acid transport, and synthesis ( Arabidopsis of a small family of genes similar to chloroquine-resistance transporter of Plasmodium falciparum ( Figure 1 , transporter 6)

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While the translational potential of Nrf2-targeted interventions is considerable, challenges remain, including risks of overactivation and oncogenicity, lack of reliable biomarkers, and barriers related to bloodbrain barrier permeability, dose, timing, and bioavailability