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Another common preclinical model involves using chemically induced damage, such as oxidative stress or inflammation, to test the peptides potential in mitigating cellular damage

In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]

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This leads to the development of (1) hyponatremia, (2) hypokalemia, (3) metabolic alkalosis, (4) low urine sodium, (5) high urine potassium excretion, and (6) high urine osmolality

(1983) ip micromelia, syndactyly, hydronephrosis and subcutaneous haemorrhage in the face, fore- and hind paws