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Similarly, people with one copy of the C allele (i.e

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After 120 h of treatment with the drugs alone or in combination, cellular toxicity was determined

Subsequent detection of elevated tHcy could, with further confirmatory testing, identify additional cases of CBS deficiency, particularly those that would be most responsive to vitamin B 6 therapy (Additional file 2: Figure S21)

Therefore, future research should focus on these aspects to provide more targeted options for clinical applications