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Phosphorylation of p16INK4A correlates with Cdk4 association

Glutathione deficiency leads to: Increased oxidative stress Accumulation of toxins and heavy metals Inability to repair DNA Cell mutation Reduced supply of oxygen and nutrients to the cells Eventual cell death People who consider themselves to be in good health may not necessarily be glutathione deficient but may still have declining glutathione levels

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Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway

If the GST tag is to be removed, a protease cleavage site may also be introduced if not present in the vector