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doi: 10.1016/j.jmb.2018.07.011 202 SimonDNWilsonKL

In this review, we discuss the role of cell death mechanisms and explore current frontiers in research, both in humans and animal models, including potential treatment opportunities

The LPS Mechanism: How a Leaky Gut Drives Systemic Disease One of the most important mechanisms through which a compromised gut damages the immune system involves a class of molecules called lipopolysaccharides, or LPS

Interestingly, iron deficiency also aggravated RM-induced AKI by enhancing catalytic heme-iron-modulated lipid peroxidation and DNA oxidation, upregulating the activity of p53/p21 and promoting cellular senescence [162]