cdk4 glutathione MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation Discovery of the GSH responsive
Discovery of the GSH responsive Y PROTACs targeting ALK and CDK4 6 as a potential treatment for cancer ScienceDirect Identification and inhibition of the Cyclin D Rb docking interface that drives cell division bioRxiv CDK4 6 inhibitor mediated cell overgrowth triggers osmotic and replication stress to promote senescence: Molecular Cell CDK2 and CDK4: Cell Cycle Functions Evolve Distinct, Catalysis Competent Conformations, Offering Drug Targets JACS Au Addressing delivery and resistance issues of CDK4 6 inhibitors as cancer therapeutics ScienceDirect
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