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Role of catalase in oxidative stress- and age-associated degenerative diseases

This activation triggers the NF-B signaling cascade, leading to a transcriptional upregulation of pro-inflammatory cytokines (e.g., TNF-, IL-1, IL-6), chemokines, and adhesion molecules, which in turn recruit more immune cells to the injury site, and driving chronic inflammation and tissue damage (85)

As we age, NAD levels naturally declineleading to fatigue, slower metabolism, and reduced mental clarity

Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis

It's also one of the few ingredients commonly recommended for both post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH)