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Plasmids, Antibodies, Inhibitors, and Metabolites All shRNAs were obtained from Sigma-Aldrich

In order to determine the role of SIRT2 in aberrant GABA production in AD, we performed astrocytic knockdown experiments in APP/PS1 animals by injecting lentiviruses carrying pSico-Scr/shSIRT2-eGFP each and AAV-GFAP-Cre-mCherry virus in the hippocampal DG (Fig