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The redox-active sulphydryl group of GSH can protect cells from ROS by directly scavenging free radicals and acting as a cofactor for antioxidant enzymes such as glutathione peroxidases (Gpx1p, Gpx2p and Gpx3p)

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Anabolic hormonal signaling, including testosterone, growth hormone, and IGF-1

However, if darkening is velvety in texture, affects skin folds in multiple areas, and has appeared alongside weight gain, it may be a sign of acanthosis nigricans a condition associated with insulin resistance

First sergeant, 37th Massachusetts Infantry, Company H