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Insulin alleviates mitochondrial oxidative stress involving upregulation of superoxide dismutase 2 and uncoupling protein 2 in septic acute kidney injury

reported that compared with control mice, Slc30a10 knockout mice are much smaller and have significantly higher levels of systemic Mn, and unexpectedly, Mn accumulation caused severe hypothyroidism in these mice 35 , even though the thyroid is not a primary site of Mn accumulation in human patients

1989;257(1 Pt 1):E65E73

SatheeshNJSamuelSMBsselbergD

Mechanisms of action of KD in neurodegeneration The classical KD is a high-fat, low-carbohydrate, and adequate-protein dietary regimen designed to mimic the metabolic effects of fasting without significant calorie restriction, thereby promoting an anabolic state [23]